LFU:online

Biochemistry, physiology and pathophysiology of key cellular signaling pathways

• overview: cell proliferation and hyper- and hypoproliferative diseases (including cancer)
• cytokines, hormones and hormone receptors: types, pathobiochemistry, signaling. assembly of signaling complexes; phosphorylation, tyrosine and sein/theronin kinases
• intracellular signaling pathways; second messengers
• regulation of cell proliferation and the cell cycle; transcription (E2Fs), phosphorylation and ubiquitination
• Signaling by the UPR: Principles, new therapeutic strategies for cancer, cardiovascular diseases, genetic disorders and neurodegeneration
• Therapeutic utilization of degradatrive cellular pathways (autophagy, Ubiquitin.signaling, proteasome) for cancer and neurodegenerative diseases 
• Therapeutic utilization of post-translational modifications such as glycosylation and sulfation
• Inflammatory Response Pathways: Principles, associated diseases, therapeutic interventions and approved drugs
• Therapeutic targeting of key signaling regulators of inflammation
• Development of new anti-inflammatory drugs: screening, identification and validation

Lecture with interactive elements involving student participation, audience response systems, online handouts

written exam