LFU:online

Primary, secondary pharmacodynamics, in vivo pharmacodynamics, preclinical animal studies, preclinical pharmacokinetics, in vivo and in vitro safety pharmacology (including immunological safety aspects). Model organisms and animal disease models, including alternatives to animal experiments/ethical aspects, GLP aspects in preclinical pharmacology

• Difference between primary and secondary pharmacodynamics
• non-clinical in vivo pharmacodynamics methodological approaches, model organisms and animal disease models (validity), including alternatives to animal, species-differences
• non-clinical animal studies (acute and repeat dose toxicity studies, genotoxicity, reproduction toxicity studies), ICH aspects
• preclinical pharmacokinetics, allometric scaling, blood brain barrier
• in vivo and in vitro safety pharmacology (including immunological safety aspects): including QT, in vitro genotoxicity; drug induced hepatotoxicity
• experiments/ethical aspects, including animal models, 3R, human tissue
• GLP aspects in preclinical pharmacology
• preclinical imaging studies, target engagement
• regulatory perspective on preclinical studies
• self-centered learning content

Lecture with interactive elements involving student participation, audience response systems, online handouts

written exam

chemistry: structures causing spec toxicities (halogen subst and liver tox, sulfonylurea structures); blood brain barrier