LFU:online

Drug research in the pharmaceutical industry today is in many qspects quite different from what it used to be only fifteen years ago. In this course the students will be introduced to the modern aspects of basic drug discovery in the preclinical setting.

Methods nowadays used in the drug discovery including: 

1. Target identification and target validation

2. Lead identification and optimization:

- Drug discovery from natural sources (e.g. plants, marine organisms, microbes, and animal sources)

- Applied synthetic methods (e.g. combinatorial synthesis, solid phase synthesis)

- Parallel synthesis (lead optimization)

3. Toxicological aspects during drug development

-Reactive drug metabolites

- Blocage of the hERG K+ receptor in the heart

Lecture (power-point presentation)

written examination

Will be discussed in the first lesson.

Subject to modification.