740100 VO Medicinal Chemistry I

winter semester 2019/2020 | Last update: 05.05.2020 Place course on memo list
740100
VO Medicinal Chemistry I
VO 3
5
weekly
annually
German

It is aim of the lecture to understand drugs, their properties and to derive basic qualities from the structure of a drug substance.

  • Structure of drug substances: properties of important functional groups
  • Molecular Basis of Drug Action: driving force for drug target interaction, differentiation pharmacodynamics vs. pharmakokinetics, ADME
  • Physicochemical properties of drugs: acidity/basicity, drug-like-properties, Lipinski's rule of five
  • Biological Membranes: a) structure of biological membranes; b) passage of drugs across membranes: possibilities and structural influences
  • Targets: a) types, structure of the most important targets; b) possibilities of drug target interactions
  • Syntheses: a) synthesis of basic structures and of selected drugs b) the concept of retrosynthesis
  • Stability/chemical instabilities of drugs: a) potentially unstable structures, b) examples for drug instabilities, c) photoinstabilities
  • Metabolism: a) General: goals of metabolism, phases, influence of drug application on metabolism, types of reactions, important drug metabolizing enzymes, results of metabolism, toxification and detoxification, influence of the chemical structure; b) examples for drugs metabolism
  • Prodrugs: classification, goals, concepts of prodrugs design and clinical applications; most important enzymes involved in prodrug activation b) examples of some important prodrugs
  • Discovery of new drugs: a) goals, concepts of drug design, drug development; b) examples

Lecture

oral

OLAT

not applicable

Subject to modification.

01.10.2019
Group 0
Date Time Location
Tue 2019-10-01
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-10-08
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-10-15
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-10-22
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-10-29
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-11-05
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-11-12
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-11-19
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-11-26
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-12-03
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2019-12-10
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2020-01-07
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2020-01-14
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2020-01-21
08.15 - 10.45 L.EG.220 L.EG.220
Tue 2020-01-28
08.15 - 10.45 L.EG.220 L.EG.220