104540 VO Bioinformatics

summer semester 2022 | Last update: 05.05.2022 Place course on memo list
104540
VO Bioinformatics
VO 2
3
Block
annually
German

Gain of basic knowledge in bioinformatics.

Attain fundamental insights into sequence analysis and major biological databases.

Overview and understanding of high throughput data analyses.

Introduction into Bioinformatics:

Challenges in bioinformatics and computational biology, basics in information technology, flow of biological information and transcriptional regulation.

Biological databases:

Genbank, NCBI, PubMed, UniProtKB/Swiss-Prot, ENSEMBL, structural and other molecular biology databases.

Biological sequence analyses:

Homology search using pairwise alignments, BLAST, database search, multiple sequence alignment, genome analyses, predictive methods for protein and DNA sequences, functional prediction, regulatory sequences and motif search, Hidden Markov models (HMM).

High throughput methods:

Gene expression analyses and next generation sequencing applications.

Data analyses and interpretation:

Machine learning, clustering, enrichment analyses, biological pathway and network analyses.

Lecture, assessment is based on a single examination at the end of the course.

written

Bioinformatics. Sequence and Genome Analysis. D.W. Mount · CSHL Press.

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. Baxevanis AD, Ouellette BF (eds) · John Wiley & Sons.

Computational Methods in Molecular Biology, Salzberg, Searls, Kasif. Elsevier.

Biological sequence analyses. Durbin, Eddy, Krogh, Mitchison. Cambridge University Press.

 A preliminary meeting for all optional modules of the master study in molecular biology will be held on March 1,2021 at 4 pm online.  It is obligatory to attend all three parts (lecture, seminar, course) to pass the module.

to be announced
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