726202 VO Structure Elucidation I (Mass spectrometry)

summer semester 2024 | Last update: 16.07.2024 Place course on memo list
726202
VO Structure Elucidation I (Mass spectrometry)
VO 2
2,5
weekly
annually
German

The students are able to:

Understand and explain methods for structure elucidation and analysis of organic compounds;

understand the basics of mass spectrometry for the identification, characterization and structural elucidation of organic compounds, including the natural isotopic abundances of the elements;

explain the operation of mass spectrometers with homogeneous and static fields and distinguish the different methods for ionization of volatile organic compounds and non-volatile (bio)molecules;

describe radical-induced and charge-induced fragmentation mechanisms of organic compounds and apply their knowledge to the calculation of isotope profiles and the use of databases for thermochemical, thermophysical and ion energy data as well as EI mass spectra.

Fundamentals of the identification, characterization and structural elucidation of organic compounds using mass spectrometry: Brief outline of the history of mass spectrometry, from atomic models and channel beams to the exploration of space and biomolecules; natural isotopic abundances of the elements as a basis for determining the elemental composition of compounds; nominal and exact mass, taking into account the mass defect due to binding energies; construction of mass spectrometers with homogeneous and static fields; separation of gaseous ions according to mass-to-charge ratio (m/z) in electric and magnetic fields; Ionization of volatile organic compounds with electron impact ionization (EI) or chemical ionization (CI) and of non-volatile (bio)molecules with matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI); radical-induced and charge-induced fragmentation mechanisms of simple organic compounds ( cleavage,  cleavage, i-cleavage, McLafferty rearrangements, onium reactions); Fragmentation of aliphatic and aromatic compounds and the effect of heteroatoms on the stability and fragmentation pathways of molecular ions; programs for calculating isotope profiles and databases for thermochemical, thermophysical and ion energy data as well as EI mass spectra.

lecture

written

Will be discussed in the first lesson.

07.03.2024
Group 0
Date Time Location
Thu 2024-03-07
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-03-14
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-03-21
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-04-11
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-04-18
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-04-18
18.30 - 20.30 M.EG.180 M.EG.180 Barrier-free Tutorium
Thu 2024-04-25
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-04-25
18.30 - 20.30 M.EG.180 M.EG.180 Barrier-free Tutorium
Fri 2024-04-26
11.30 - 13.00 L.EG.200 L.EG.200 Barrier-free Tutorium
Thu 2024-05-02
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-05-02
18.30 - 20.30 M.EG.180 M.EG.180 Barrier-free Tutorium
Thu 2024-05-16
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-05-16
18.30 - 20.30 M.EG.180 M.EG.180 Barrier-free Tutorium
Thu 2024-05-23
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-05-23
18.30 - 20.30 M.EG.180 M.EG.180 Barrier-free Tutorium
Thu 2024-06-06
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-06-06
18.30 - 20.30 M.EG.180 M.EG.180 Barrier-free Tutorium
Thu 2024-06-13
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-06-13
18.30 - 20.30 M.EG.180 M.EG.180 Barrier-free Tutorium
Fri 2024-06-14
11.30 - 13.00 M.EG.180 M.EG.180 Barrier-free Tutorium
Tue 2024-06-18
11.30 - 13.00 L.01.220 L.01.220 Tutorium
Thu 2024-06-20
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-06-20
18.30 - 20.30 M.EG.180 M.EG.180 Barrier-free Tutorium
Fri 2024-06-21
11.30 - 13.00 M.EG.180 M.EG.180 Barrier-free Tutorium
Tue 2024-06-25
11.30 - 13.00 L.01.220 L.01.220 Tutorium
Thu 2024-06-27
08.30 - 10.00 L.EG.200 L.EG.200 Barrier-free
Thu 2024-06-27
18.30 - 20.30 M.EG.180 M.EG.180 Barrier-free Tutorium
Tue 2024-07-16
12.30 - 14.00 L.01.220 L.01.220 2. Prüfungstermin
Wed 2024-09-18
09.00 - 11.00 L.02.122 L.02.122 3. Prüfungstermin
Group Booking period Date of exam
726202-0 2024-06-06 08:30 - 2024-06-25 23:59
2024-06-27
8:30-10:00
CCB, L.EG.200
Breuker K., Müller T.
726202-0 2024-06-19 10:00 - 2024-07-15 23:59
2024-07-16
12:30-14:00
CCB, L.01.122
Breuker K., Müller T.
726202-0 2024-07-01 15:00 - 2024-09-16 23:59
2024-09-18
9:00-10:30
CCB, L.02.122
Register exam
Breuker K., Müller T.